Copy Number Variations in Candidate Genes in Neovascular Age-Related Macular Degeneration

Measurement of Choroidal Neovascular Area in Age-Related Macular Degeneration using Modified Otsu’s Thresholding Method

Introduction: Age-related Macular Degeneration (AMD) is one of the most important causes of irreversible  blindness in the developed world and  prevents the affected  person from  performing simple tasks such  as  reading,  driving  and  facial  recognition.  In  the  AMD,  new  blood  vessels  grow  underneath  the  retina  in  a  process  called  choroidal  neovascularisation  (CNV).  There  ...

Neovascular Age - Related Macular Degeneration

Ranibizumab in neovascular age-related macular degeneration

BACKGROUND Ranibizumab--a recombinant, humanized, monoclonal antibody Fab that neutralizes all active forms of vascular endothelial growth factor A--has been evaluated for the treatment of neovascular age-related macular degeneration. METHODS In this multicenter, 2-year, double-blind, sham-controlled study, we randomly assigned patients with age-related macular degeneration with either minima...

Copy number variation in the complement factor H-related genes and age-related macular degeneration

PURPOSE To determine the contribution of copy number variation (CNV) in the regulation of complement activation (RCA) locus to the development of age-related macular degeneration (AMD). METHODS A multiplex ligation-dependent probe amplification assay was developed to quantify the number of copies of CFH, CFHR3, CFHR1, CFHR4, CFHR2, and CFHR5 in humans. Subjects with (451) and without (362) AM...

Pegaptanib for neovascular age-related macular degeneration.

(1) Neovascular (wet) age-related macular degeneration (AMD) results from the growth of abnormal blood vessels under the retina (choroidal neovascularization). Sudden and permanent vision loss occurs as these vessels grow, leak, bleed, and scar. (2) A human protein, vascular endothelial growth factor (VEGF), is implicated in the development of wet AMD. Pegaptanib attaches to VEGF and blocks its...